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Insider Stock Ownership

Name	Relationship / Title	Current Shares	Trading Activity
adelman robert j	Director	1,231,936	View
Date	Type	Shares Traded	Price Range USD
07/19/2005	Acquisition (Non Open Market)	1,096,936	n/a
07/13/2005	Buy	135,000	11.00
ayers gregory m	Director	32,891	View
Date	Type	Shares Traded	Price Range USD
01/18/2006	Changes in Beneficial Ownership	2,469	0.00
08/30/2006	Sell	300	2.25
08/29/2006	Sell	4,700	2.23 - 2.41
08/16/2006	Sell	1,468	2.19 - 2.21
08/15/2006	Sell	2,083	2.25 - 2.35
08/14/2006	Sell	1,449	2.37 - 2.45
07/13/2005	Statement of Ownership	0	n/a
07/13/2005	Buy	100	11.00
barold helen s	Officer	2,000	View
Date	Type	Shares Traded	Price Range USD
08/15/2007	Buy	1,000	3.49
09/13/2006	Buy	1,000	3.12
brennan edward f	Officer	478,408	View
Date	Type	Shares Traded	Price Range USD
04/08/2008	Acquisition (Non Open Market)	300,000	n/a
01/09/2008	Acquisition (Non Open Market)	120,000	n/a
06/27/2007	Option Execute	10,000	0.62
03/30/2006	Buy	5,671	3.04
03/15/2006	Buy	483	1.91
07/13/2005	Statement of Ownership	0	n/a
cooney david j	Director	521,496	View
Date	Type	Shares Traded	Price Range USD
07/19/2005	Option Execute	24,386	8.37
07/19/2005	Disposition (Non Open Market)	18,558	n/a
07/19/2005	Acquisition (Non Open Market)	452,110	n/a
07/13/2005	Buy	45,000	11.00
hattendorf joseph mark	Director	4,000	View
Date	Type	Shares Traded	Price Range USD
08/14/2006	Buy	4,000	2.19 - 2.50
07/13/2005	Statement of Ownership	0	n/a
minocherhomjee arda	Director	1,944,961	View
Date	Type	Shares Traded	Price Range USD
04/24/2007	Buy	96,553	5.14
07/19/2005	Acquisition (Non Open Market)	1,645,408	n/a
07/13/2005	Buy	203,000	11.00
mpm bioventures ii qp lp	Beneficial Owner (10% or more)	3,028,082	View
Date	Type	Shares Traded	Price Range USD
04/24/2007	Buy	96,551	5.14
07/19/2005	Option Execute	121,940	8.37
07/19/2005	Disposition (Non Open Market)	92,790	n/a
07/19/2005	Acquisition (Non Open Market)	2,722,381	n/a
07/13/2005	Buy	180,000	11.00
orbimed advisors llc	Beneficial Owner (10% or more)	389,432	View
Date	Type	Shares Traded	Price Range USD
06/14/2007	Disposition (Non Open Market)	842,504	n/a
07/13/2005	Statement of Ownership	0	n/a
07/13/2005	Acquisition (Non Open Market)	1,096,936	n/a
07/13/2005	Sell	135,000	11.00
tibbitts gregory j	Officer	196,037	View
Date	Type	Shares Traded	Price Range USD
04/08/2008	Acquisition (Non Open Market)	100,000	n/a
01/09/2008	Acquisition (Non Open Market)	40,000	n/a
06/27/2007	Option Execute	10,000	0.62
03/29/2006	Buy	3,300	3.00
03/15/2006	Buy	483	1.91
07/13/2005	Statement of Ownership	0	n/a
wheeler kurt	Director	3,028,082	View
Date	Type	Shares Traded	Price Range USD
04/24/2007	Buy	96,551	5.14
07/19/2005	Option Execute	121,940	8.37
07/19/2005	Disposition (Non Open Market)	92,790	n/a
07/19/2005	Acquisition (Non Open Market)	2,722,381	n/a
07/13/2005	Buy	180,000	11.00
william blair capital management vii, llc	Beneficial Owner (10% or more)	1,944,961	View
Date	Type	Shares Traded	Price Range USD
04/24/2007	Buy	96,553	5.14
07/19/2005	Acquisition (Non Open Market)	1,645,408	n/a
07/13/2005	Buy	203,000	11.00

Stock ownership information provided by EDGAR Online. This information is based on the the lastest electronic filed with the SEC for each owner. If an owner has not filed with the SEC electronically since the Mandated Electronic Filing and Web site Posting for Forms 3, 4 and 5 SEC rule went into effect on June 30, 2003 then they will not appear on this page.